# Low-Dose CT Quality Assurance at Scale: Automated Detection of Overscanning, Underscanning, and Image Noise

**Authors:** Patrick Wienholt, Alexander Hermans, Robert Siepmann, Christiane Kuhl, Daniel Pinto dos Santos, Sven Nebelung, Daniel Truhn

PMC · DOI: 10.3390/life16010152 · Life · 2026-01-16

## TL;DR

This paper introduces an AI tool that automatically checks the quality of low-dose CT scans for lung screening, reducing manual work and improving consistency.

## Contribution

A fully automated AI tool for LDCT quality assurance that measures scan coverage and image noise without user input.

## Key findings

- The AI achieved high accuracy in segmenting lungs and aorta in 90.8% and 96.9% of cases, respectively.
- Across 38,834 scans, significant overscanning and minor underscanning were observed, indicating protocol deviations.
- The tool supports large-scale quality monitoring and dose optimization by enabling exception-based human oversight.

## Abstract

Automated quality assurance is essential for low-dose computed tomography (LDCT) lung screening, yet manual checks strain clinical workflows. We present a fully automated artificial intelligence tool that quantifies scan coverage and image noise in LDCT without user input. Lungs and the aorta are segmented to measure cranial/caudal over- and underscanning, and noise is computed as the standard deviation of Hounsfield units (HUs) within descending aortic blood, normalized to a 1 mm3 voxel. Performance was verified in a reader study of 98 LDCT scans from the National Lung Screening Trial (NLST), and then applied to 38,834 NLST scans reconstructed with a standard kernel. In the reader study, lung masks were rated ≥“Nearly Perfect” in 90.8% and aorta-blood masks in 96.9% of cases. Across 38,834 scans, mean overscanning distances were 31.21 mm caudally and 14.54 mm cranially; underscanning occurred in 4.36% (caudal) and 0.89% (cranial). The tool enables objective, large-scale monitoring of LDCT quality—reducing routine manual workload through exception-based human oversight, flagging protocol deviations, and supporting cross-center benchmarking—and may facilitate dose optimization by reducing systematic over- and underscanning.

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138)

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12842913/full.md

## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC12842913/full.md

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Source: https://tomesphere.com/paper/PMC12842913