# Topical and Mucoadhesive Administration of Capsaicin in the Burning Mouth Syndrome Treatment

## TL;DR

A mucoadhesive capsaicin treatment significantly reduced burning mouth syndrome pain in most patients, with effects lasting up to three months.

## Contribution

This study introduces a novel mucoadhesive bilayer polymer formulation of capsaicin for topical treatment of BMS.

## Key findings

- Over 86% of patients experienced reduced burning sensations after capsaicin treatment.
- Pain reduction was sustained at 3-month follow-up in most patients.
- Gender, taste disturbances, depression, and age significantly influenced pain scores.

## Abstract

Background/Objectives: Burning Mouth Syndrome (BMS) is a common oral condition in older women and is characterized by a multifactorial etiology. To date, no standardized treatment strategy has been established. The aim of this study was to evaluate the effectiveness of topical application of capsaicin (0.025 mg/cm2) in the form of a mucoadhesive bilayer polymer reducing burning sensations in BMS. The study assessed levels of depression, sleep disturbances, and quality of life. Material and Methods: The proof-of-concept study included 29 patients with symptoms of BMS. The peripheral origin of BMS was confirmed by lingual nerve block. Pain intensity was assessed using the Numeric Rating Scale (NRS-11) and the Short-Form McGill Pain Questionnaire (SF-MPQ). Depression, sleep disturbances, and quality of life were evaluated using the Beck Depression Inventory (BDI), Athens Insomnia Scale (AIS), and WHO Quality of Life Questionnaire (WHOQoL). Results: A reduction in pain was observed in over 86% patients. Decrease in burning at treatment sites was recorded immediately after treatment and also at the 3-month follow-up. Gender, taste disturbances, depression, and age were found to have a significant effect on final NRS-11 scores. Conclusions: Significant reduction in pain intensity was achieved in nearly all treated patients, with adverse effects being rare.