Silicon Nitride Bioceramics with TiC Additives: Excellent Mechanical Properties, Cytocompatibility, and Antibacterial Properties

TL;DR

This paper explores how adding TiC to silicon nitride improves its strength, cell compatibility, and antibacterial properties for use in bone implants.

Contribution

The study introduces TiC-modified silicon nitride as a novel bioceramic with enhanced mechanical and biological properties.

Findings

Adding 3-5% TiC improved flexural strength and fracture toughness of silicon nitride.

All TiC-modified silicon nitride samples showed good cell compatibility and antibacterial efficacy against S. aureus and E. coli.

Surface Ti enrichment and continuous Si ion release were observed across all TiC-modified samples.

Abstract

Silicon nitride is a type of bioceramic with great application potential. However, the brittleness of silicon nitride can be addressed through toughening. In this study, various proportions of TiC were incorporated into the sintering additive system to explore the effects of different amounts of TiC on the mechanical properties, cell compatibility, and antibacterial properties of silicon nitride. Silicon nitride was prepared by gas pressure sintering, with TiC addition amounts of 3%, 5%, 8%, and 13% wt. Among the four types of silicon nitride, the mechanical properties of silicon nitride with 3% and 5% wt TiC addition were improved, with the flexural strength and fracture toughness of the former being 571 MPa and 8.35 MPa·m1/2, respectively, and the flexural strength and fracture toughness of the latter being 532 MPa and 8.53 MPa·m1/2, respectively. The surface of all four types of silicon nitride was enriched with Ti as the amount of TiC added increased, and the surface properties of the four silicon nitrides were the same. All four types of silicon nitride could continuously release Si ions in liquid. In vitro cell experiments showed that all four types of silicon nitride could enable normal cell proliferation and adhesion. Silicon nitride with different TiC addition amounts all exhibited good cell compatibility. Compared with the control material, each of the four types of silicon nitride demonstrated robust antibacterial efficacy against Staphylococcus aureus and Escherichia coli, with comparable potency across all types. These findings indicate that the incorporation of titanium carbide (TiC) within the silicon nitride matrix, particularly within the 3–5% weight ratio range, not only enhances mechanical integrity and cellular compatibility, but also confers notable antibacterial attributes. Consequently, these results demonstrate the promising viability of TiC-modified silicon nitride as a prospective material for the fabrication of bone implants.

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