Preoperative Metabolic Risk Factors and Outcomes in Living Donor Liver Transplant in HBV Recipients

TL;DR

This study examines how preoperative metabolic risk factors affect outcomes in liver transplant patients with HBV, finding no significant differences in postoperative complications.

Contribution

The study provides new insights into the impact of metabolic risk factors on liver transplant outcomes in HBV patients.

Findings

No significant difference in postoperative mortality, infections, or biliary complications between groups.

Obesity was not significantly linked to increased postoperative complications.

Bleeding complications were more frequent in obese patients but not statistically significant.

Abstract

Objective: Additional preoperative risk factors may influence the prognosis of patients diagnosed with HBV. This study aims to compare the effects of cirrhosis patients with HBV with and without risk factors on post-transplant follow-ups and postoperative complications. Materials and Method: The study included patients with HBV who underwent living donor liver transplantation (LDLT) at Demiroğlu Bilim University, Şişli Liver Transplant Center, Istanbul, Türkiye, between 2004 and 2019. The data from 319 patients were retrospectively analyzed. Those without preoperative risk factors were classified as group 1 (n = 214), and those with risk factors were classified as group 2 (n = 105). These patients were compared in terms of complications during their postoperative follow-up. The Student’s t-test, ANOVA test, Mann–Whitney U test, Kruskal–Wallis test, chi-squared test, and Fisher’s exact test were used, and p < 0.05 was considered statistically significant. Results: When group 1 and group 2 were compared in terms of postoperative mortality, infections, bleeding complications, and biliary system complications, no statistically significant difference was found [(8.87% vs. 9.52% p = 0.62), (28.80% vs. 20.24%, p = 0.95), (6.10% vs. 8.70%, p = 0.35), (12.7% vs. 9.60% p = 0.19, respectively)]. Although bleeding complications were numerically found more frequent in patients with obesity, this difference did not reach statistical significance (23.02% vs. 6.10% p = 0.08). Conclusions: Obesity was not significantly associated with postoperative complications and may be influenced by accompanying comorbidities.