Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation

TL;DR

This review explores how melanin functions in the body and how natural products can be used to control pigmentation.

Contribution

The paper provides a comprehensive overview of natural product-based strategies for modulating melanogenesis and their mechanisms.

Findings

Natural products modulate melanogenesis through tyrosinase regulation and signaling pathways like ERK/MAPK and cAMP/PKA/CREB.

Phytochemicals and plant polyphenols show anti-melanogenic effects via enzymatic inhibition and antioxidant activities.

Some flavonoids and phenolics stimulate pigmentation by enhancing melanogenic signaling and MITF-driven transcription.

Abstract

Melanin produced in melanocytes contributes to photoprotection, oxidative stress reduction, immune regulation, and epidermal homeostasis, while its dysregulation underlies diverse pigmentary disorders. Natural products modulate melanogenesis by regulating tyrosinase activity, intracellular signaling pathways such as extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) and cyclicAMP/protein kinase A/cAMP response element-binding protein (cAMP/PKA/CREB), and cellular redox balance. Anti-melanogenic effects have been reported for various fruit-derived phytochemicals, ginseng-based metabolites, and plant polyphenols, which act through direct enzymatic inhibition, suppression of melanoenic signaling, modulation of melanosome dynamics, and antioxidant or anti-inflammatory activities. Advances in delivery systems, including nano- and microencapsulation platforms, further enhance the stability and topical bioavailability of these compounds. In contrast, certain methoxylated flavonoids and phenolic constituents can stimulate pigmentation by sustaining melanogenic signaling and promoting microphthalmia-associated transcription factor (MITF)-driven transcription, emphasizing the context-dependent and bidirectional influence of natural substances on pigmentation outcomes. Collectively, these findings highlight the therapeutic potential of natural product-based modulators of melanogenesis while underscoring the need for mechanistic clarification, safety evaluation, and translational studies to ensure effective and controlled pigmentation management. This review summarizes the biological functions of melanin and examines natural strategies for regulating pigmentation.

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