# Preparation Strategy of Hydrogel Loaded with Natural Products and Its Research Progress in Skin Repair

## TL;DR

This paper reviews how hydrogels loaded with natural products help repair skin wounds through various mechanisms and preparation methods.

## Contribution

The paper introduces the cross-linking mechanisms and construction modes of natural product-loaded hydrogels for skin repair.

## Key findings

- Hydrogels with natural products aid in skin repair through hemostasis, antibacterial, and anti-inflammatory actions.
- Physical and chemical cross-linking methods are used to prepare these hydrogels.
- The study outlines self-assembly and physical parcel construction modes for hydrogel development.

## Abstract

Hydrogels are three-dimensional hydrophilic network structures with one or more polymers cross-linked, with excellent biocompatibility, drug-carrying function, and biodegradability. Meanwhile, skin wound repair includes hemostasis and coagulation, an inflammation stage, a proliferation stage, and a remodeling stage. Therefore, hydrogels loaded with natural products are widely used in repairing skin wounds through various mechanisms such as hemostasis, antibacterial activity, anti-inflammatory activity, angiogenesis promotion, skin regeneration, and skin repair monitoring. In addition, this study provides the cross-linking mechanism (physical cross-linking and chemical cross-linking) and construction mode (self-assembly and physical parcels) of the loaded natural product hydrogel. In general, the purpose of this paper is to comprehensively understand the mechanism and preparation strategy of hydrogels loaded with natural products for skin repair and provide theoretical reference for future skin repair research.