MGMT, NUPR1, NDRG2, and GLI1 Gene Promoter Methylation in Glioblastoma Tissues and Association with Clinical Characteristics and Therapeutic Outcomes
Mariam M. Gabr, Sherihan G. AbdelHamid, Lobna R. Ezz El Arab, Menha Swellam, Nadia M. Hamdy
TL;DR
The study identifies gene promoter methylation patterns in glioblastoma that correlate with survival and treatment response, offering potential for personalized therapy.
Contribution
A novel multi-gene methylation panel is proposed to better understand glioblastoma heterogeneity and improve prognostic modeling.
Findings
NDRG2 methylation is an independent predictor of neoplastic lesions in glioblastoma.
NUPR1 hypermethylation is associated with lower mortality risk and better response to temozolomide therapy.
MGMT and NUPR1 methylation status are strongly correlated and linked to improved survival outcomes.
Abstract
Glioblastoma (GBM) is the most prevalent and devastating form of primary brain tumors in adults, with dismal survival despite advancements in treatment modalities. The current study sought to develop clinically significant prognostic models for GBM patients by comprehensively profiling MGMT, NUPR1, NDRG2, and GLI1 gene promoter methylation in GBM tissues vs. non-neurooncological disease (NND) and their association with clinical characteristics and therapeutic outcome. This was further evaluated by in silico functional enrichment analysis. NUPR1, NDRG2, and GLI1 gene promoter methylation were significant epigenetic discriminators between GBM and NND. However, NDRG2 methylation was the sole independent predictor for neoplastic lesions (OR = 1.71, 95% CI [1.25–3.57], p = 0.028). Multivariable Cox regression analysis revealed that NUPR1 promoter hypermethylation was significantly correlated…
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Taxonomy
TopicsMechanisms of cancer metastasis · Chromatin Remodeling and Cancer · FOXO transcription factor regulation