Seed Oil of Lycium barbarum L. from Qaidam Basin Prevents and Treats UV-Induced Photodamage in BABL/c Mice Skin by Modulating Skin Microbiome and Amino Acid Metabolism
Le Han, Yongjing Yang, Benyin Zhang, Yuting Wang, Yiming Ji, Shasha Du, Yongqiang Zou
TL;DR
Seed oil from Lycium barbarum in the Qaidam Basin protects mouse skin from UV damage by balancing skin microbes and amino acid metabolism.
Contribution
QLBSO's novel protective effects against UV-induced skin damage are linked to microbiome and amino acid metabolism modulation.
Findings
QLBSO reduced UV-induced skin damage and inflammation in BALB/c mice.
QLBSO restored skin microbiota balance and corrected amino acid metabolism disruptions.
Key microbes and metabolites like Firmicutes_A and cysteine were identified as responsive to QLBSO.
Abstract
Ultraviolet (UV) radiation is a primary environmental factor responsible for skin photodamage, and exposure to UV rays is strongly linked to a variety of skin diseases. This study examined the prophylactic and therapeutic effects of Seed Oil of Lycium barbarum L. from the Qaidam basin (QLBSO) in a UV-induced skin photodamage model in BALB/c mice, exploring potential mechanisms by analyzing the skin microbiota and metabolites using 16S rDNA sequencing and metabolomics. The results showed that QLBSO effectively alleviated UV-induced histopathological changes in mouse skin. It also significantly increased the activity of superoxide dismutase (SOD) and catalase (CAT) in UV-damaged skin tissue, while reducing levels of inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), as well as matrix metalloproteinases-1 (MMP-1) and MMP-3.…
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Taxonomy
TopicsSkin Protection and Aging · Dermatology and Skin Diseases · Biocrusts and Microbial Ecology