Genome-Based Evaluation of Safety and Probiotic Traits in Infant Feces-Sourced Bifidobacterium animalis subsp. lactis BD1
Meng Tian, Zihao Liu, Jiahang Li, Jialin Wang, Dayong Ren, Yue Leng
TL;DR
This study evaluates the safety and probiotic potential of a Bifidobacterium strain from infant feces, finding it safe and effective for use as a probiotic.
Contribution
The study provides a comprehensive safety and functional characterization of a novel infant-derived Bifidobacterium strain.
Findings
BD1 has a favorable safety profile with minimal antibiotic resistance and no major toxins.
The strain shows strong bile salt tolerance and biofilm-forming potential.
BD1 has rich metabolic capabilities for carbohydrates and amino acids.
Abstract
Bifidobacterium animalis subsp. lactis is a widely used probiotic, yet its efficacy is highly strain-specific, and growing antibiotic resistance necessitates rigorous safety evaluations. We used whole-genome sequencing and in vitro assays to characterize the safety and probiotic traits of infant feces-sourced strain BD1, which shows preliminary mood-modulating and anti-inflammatory potential. The BD1 genome showed a favorable safety profile. VFDB analysis identified 139 low-similarity homologs, with no major toxins detected. Only four chromosomally encoded antibiotic resistance genes were found; phenotypic testing confirmed resistance solely to tetracycline and mupirocin. Although the tetracycline resistance gene tet(W) was identified in genomic island GI01, the absence of associated mobile genetic elements results in a negligible risk of its mobilization. Functional annotation…
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Taxonomy
TopicsProbiotics and Fermented Foods · Gut microbiota and health · Clostridium difficile and Clostridium perfringens research