# Assessment of Aggression and Anger Levels in Athletes: A Study on Gene Polymorphisms in Forensic Science

**Authors:** Buse Sabiha Bozaslan, Emel Hulya Yukseloglu, Nazli Holumen, Itir Erkan, Faruk Celik, Murat Diramali, Sermin Durak, Sakir Umit Zeybek

PMC · DOI: 10.3390/genes17010011 · 2025-12-23

## TL;DR

This study explores how genetic variations in athletes may be linked to aggression and anger, using specific genes related to behavior.

## Contribution

The study introduces a forensic science perspective on genetic influences on aggression in athletes.

## Key findings

- Gene-specific patterns were observed in 5-HTT, MAO-A, and COMT.
- No clear pattern was found for the 5-HT1A gene.
- The study highlights preliminary genetic associations with aggression in sports.

## Abstract

Background/Objectives: Many studies in the literature are increasingly focusing on how genes influence the development of individual behaviors and personality traits through genome sequencing. Most research indicates that complex behaviors and their characteristics are influenced by multiple genes, highlighting the crucial role of genetic studies in this field. Behavioral genetics, as a scientific discipline, investigates how genetic factors shape individuals’ behaviors and personality traits. The concepts of violence and aggression, observable in various contexts, have been extensively studied, with a particular focus on the underlying causes of these behaviors. In sports, where physical strength plays a significant role, regulations designed to prevent violent behaviors and aggressive attitudes contribute to the establishment of appropriate behavior patterns and discipline. Methods: This study aims to identify correlations between polymorphisms found in athletes and their responses to questionnaires, focusing on candidate genes known to influence personality and behavior traits, such as catechol-O-methyltransferase (COMT), serotonin transporter (5-HTT), monoamine oxidase (MAO-A), and serotonin 1A transporter (5-HT1A). A total of twenty licensed athletes participated in the study. Participants completed three standardized instruments: the Sportsmanship Behavior Scale (27 items), the Sports Emotion Scale (22 items), and the Anger-Control Scale (34 items). Following the acquisition of informed consent, buccal swab samples were collected for single nucleotide polymorphism (SNP) analysis targeting the COMT, MAO-A, 5- HT1A, and 5-HTT genes. Subsequent to sample collection and questionnaire administration, statistical analyses were conducted to evaluate the relationships among behavioral measures and genetic variants. Results: Overall, the findings point to gene-specific patterns in 5-HTT, MAO-A, and COMT, while no clear pattern emerged for 5-HT1A. Conclusions: Ultimately, this study provides an early exploration of aggression-related genetic patterns within the context of forensic sciences, highlighting preliminary trends and potential associations that may inform the design of future research.

## Linked entities

- **Genes:** COMT (catechol-O-methyltransferase) [NCBI Gene 1312], SLC6A4 (solute carrier family 6 member 4) [NCBI Gene 6532], MAOA (monoamine oxidase A) [NCBI Gene 4128], HTR1A (5-hydroxytryptamine receptor 1A) [NCBI Gene 3350]

## Full-text entities

- **Genes:** HTR1A (5-hydroxytryptamine receptor 1A) [NCBI Gene 3350] {aka 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21}, SLC6A4 (solute carrier family 6 member 4) [NCBI Gene 6532] {aka 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT}, MAOA (monoamine oxidase A) [NCBI Gene 4128] {aka BRNRS, MAO-A}, COMT (catechol-O-methyltransferase) [NCBI Gene 1312] {aka HEL-S-98n}
- **Diseases:** Aggression (MESH:D010554), violent behaviors (MESH:D001523)

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Source: https://tomesphere.com/paper/PMC12841106