Multi-Responsive and Antibacterial Dynamic Covalent Hydrogels Cross-Linked by Amphiphilic Copolymer Micelles
Yuyao Wang, Dou Jin, Zichen Huang, Fan Chen, Kun Liu, Xiacong Zhang
TL;DR
This paper introduces a new type of hydrogel that responds to multiple stimuli and has antibacterial properties, suitable for wound healing and drug delivery.
Contribution
A novel dynamic covalent hydrogel platform is developed using amphiphilic copolymer micelles with tunable responsiveness and antibacterial activity.
Findings
The hydrogel degrades under acidic, alkaline, glucose, or H2O2 conditions.
The Gel showed strong antibacterial activity against S. aureus.
The material has a porous structure that allows efficient drug encapsulation and release.
Abstract
Dynamic covalent hydrogels exhibiting multi-responsive and antibacterial properties offer significant potential for biomedical applications, including smart wound dressings and controlled drug delivery. Herein, a series of amphiphilic quaternized copolymers (Q-C8PEG-n) with tunable quaternization degrees was synthesized from C8PEG via iodomethane addition and characterized by 1H NMR, COSY, FTIR, UV-vis spectroscopy, DLS, TEM, and zeta potential analyses, confirming successful quaternization and micelle formation. These copolymers displayed thermosensitive behavior, with cloud point temperatures increasing due to enhanced hydrophilicity. Q-C8PEG-3 micelles, incorporating diethanolamine units, were crosslinked with phenylboronic acid-grafted hyaluronic acid (HA-PBA) to yield dynamic covalent hydrogels (Gel) through reversible boronic ester bonds stabilized by B-N coordination. The Gel…
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Taxonomy
TopicsHydrogels: synthesis, properties, applications · Wound Healing and Treatments · Antimicrobial agents and applications