The Potential Link and Role of Zyxin in the Pathogenesis of Psoriasis and Its Associated Comorbidities

TL;DR

This study found higher zyxin levels in psoriasis patients but did not link it to disease severity or other health factors.

Contribution

The study is the first to report elevated serum zyxin levels in psoriasis patients compared to healthy controls.

Findings

Serum zyxin levels were significantly higher in psoriasis patients than in healthy controls.

No significant correlations were found between zyxin levels and inflammatory or metabolic parameters.

Zyxin levels did not correlate with psoriasis disease severity as measured by PASI scores.

Abstract

Psoriasis is a chronic inflammatory disorder with immunological, metabolic, and environmental components. It affects not only the skin but also the nails, joints, and vascular system. A total of 50 patients with psoriasis and 28 healthy controls took part in this study. Serum samples were gathered both from the psoriatic group and the control group. Serum zyxin concentrations were measured via enzyme-linked immunosorbent assay (ELISA). Our results revealed that serum zyxin amounts were significantly higher in patients with psoriasis compared with the controls. However, no statistically significant correlations were found between serum zyxin levels and inflammatory or metabolic parameters in the psoriasis group. Similarly, there was no significant correlation between zyxin level and disease severity as assessed by the Psoriasis Area and Severity Index (PASI) score. To sum up, our study demonstrates that serum zyxin levels are significantly elevated in patients with psoriasis compared with controls. Nevertheless, the precise role of zyxin in the aetiology of psoriasis remains unclear. Further research is needed to clarify the function of this protein in the disease process and to explore its potential as a therapeutic target.

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