Bioinformatic Analysis of Differentially Expressed Long Non-Coding RNAs in Skeletal Muscle Following Aerobic and Resistance Exercise

TL;DR

This study explores how different types of exercise affect long non-coding RNA in skeletal muscle, suggesting they play distinct roles in muscle adaptation.

Contribution

The study identifies distinct lncRNA profiles in skeletal muscle following acute aerobic and resistance exercise.

Findings

Distinct lncRNA profiles were observed between acute aerobic and resistance exercise at different timepoints.

lncRNA may perform unique roles in controlling muscle responses to different exercise types.

lncRNA expression changes suggest potential regulatory roles in exercise adaptation.

Abstract

Background/Objectives: Emerging evidence suggests that long non-coding RNA (lncRNA) molecules influence the adaptive response to exercise, but how lncRNA responses differ between endurance and resistance exercise (RE) modalities is poorly understood. The purpose of this study was to bioinformatically infer the expression of lncRNA in skeletal muscle following acute aerobic exercise (AE) and RE. Methods: We downloaded publicly available RNA-seq data, performed a differential expression (DE) analysis, and compared lncRNA expression profiles between different exercise types (AE vs. RE) at three timepoints: baseline, 1 h post-exercise, and 4 h post-exercise. Results: We observed distinct lncRNA profiles between acute AE and RE at different timepoints, suggesting that lncRNA perform distinct roles in controlling the response to different exercise modalities in skeletal muscle. Conclusions: Future studies should investigate the specific roles of these lncRNAs in the response to acute exercise in skeletal muscle.

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