Cholesterol Metabolism: An Ally in the Development and Progression of Cervical Cancer

TL;DR

This review explores how cholesterol metabolism supports cervical cancer development and progression, and its potential as a therapeutic target.

Contribution

The paper highlights the role of cholesterol metabolism in cervical cancer, particularly under the influence of HPV E6 and E7 oncoproteins.

Findings

Cholesterol metabolism alterations significantly influence cervical cancer progression and patient outcomes.

E6 and E7 oncoproteins exacerbate cholesterol metabolism elements, as shown by omics studies.

Targeting cholesterol metabolism may reduce tumor growth and improve antitumor immunity.

Abstract

Despite screening programs and vaccination campaigns, cervical cancer (CC) remains a health problem worldwide. The involvement of the E6 and E7 oncoproteins of Human Papillomavirus (HPV) is crucial for the development and progression of this type of cancer. Metabolic reprogramming by cancer cells has gained relevance in the last decade due to its ability to promote cell growth, survival, invasion, metastasis, and resistance to therapy. In this review, we focus on alterations in cholesterol metabolism that significantly influence the development and progression of CC, as well as the clinical outcome of patients. Furthermore, evidence from comprehensive omics studies suggesting that E6 and E7 are involved in the exacerbation of elements related to cholesterol metabolism is analyzed. Preclinical and clinical studies are also discussed that demonstrate that cholesterol metabolism is a potential therapeutic target, highlighting its impact on reducing tumor growth, altering the tumor microenvironment, and improving antitumor immunity.

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