Biomedical Interpenetrated Hydrogels Fabricated via Quaternary Ammonium Chitosan and Dopamine-Conjugated Gelatin Integrated with Genipin and Epigallocatechin Gallate
Ling Wang, Shuxin Hu, Zheng Wei, Peng Ding, Yaling Deng, Yanting Han, Yanfang Sun, Guohua Jiang, Lei Nie
TL;DR
This paper introduces a new type of biomedical hydrogel with self-healing, antibacterial, and cell-friendly properties for tissue regeneration.
Contribution
A novel interpenetrated hydrogel is developed using dopamine-gelatin and quaternary ammonium chitosan with EGCG for multifunctional biomedical use.
Findings
The hydrogels show self-healing properties and strong adhesion to various materials and organs.
They exhibit antibacterial activity against Escherichia coli and Staphylococcus aureus.
The hydrogels have good antioxidant activity, hemocompatibility, and cell migration ability.
Abstract
Multifunctional hydrogels with an interpenetrated network structure have shown great potential for biomedical and tissue-regeneration applications. In this work, the biomedical hydrogel was fabricated with an interpenetrated network based on dopamine grafted gelatin (DA-Gel), and genipin crosslinked quaternary ammonium chitosan (QCS), incorporating epigallocatechin gallate (EGCG). The EDC/NHS and Schiff-base bond connections occurred in the hydrogels, as confirmed by Fourier-transform infrared (FT-IR) analysis. The properties of the fabricated hydrogels, including microstructure, degradation rate, adhesive strength, mechanical strength, and rheological behavior, can be regulated by adjusting the DA-Gel/QCS ratio or by using different crosslinking approaches. In addition, the fabricated hydrogels exhibited self-healing properties and strong adhesion to various materials and organs.…
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Taxonomy
TopicsHydrogels: synthesis, properties, applications · Nanocomposite Films for Food Packaging · Wound Healing and Treatments