TUDCA Ameliorates Cognitive Impairment in APP/PS1 Mice by Modulating the Microbiota–Gut–Brain Axis
Minxia Zhan, Hui Chen, Xunzhong Fu, Shijin Tang, Xiaoxian Song, Henghua Li, Liancai Zhu, Bochu Wang
TL;DR
TUDCA improves cognitive function in Alzheimer's disease mice by affecting gut health and brain inflammation.
Contribution
This study reveals that TUDCA improves cognition in AD mice via microbiota-gut-brain axis modulation and independent mechanisms.
Findings
TUDCA reduced amyloid-beta accumulation and inflammation in the brain and peripheral tissues.
TUDCA improved gut barrier function and altered gut microbiota composition.
Fecal microbiota transplantation showed TUDCA-modulated microbiota improved memory in AD mice.
Abstract
Tauroursodeoxycholic acid (TUDCA), a bile acid conjugate, has been suggested to improve cognition in models of Alzheimer’s disease (AD), although its underlying mechanisms remain unclear. This study aimed to evaluate the effects of TUDCA and its potential pathways in APP/PS1 mice. Behavioral tests, assessments of amyloid-β (Aβ) deposition, neuroinflammation, peripheral inflammatory responses, intestinal barrier integrity, and gut microbiota composition were performed, along with pseudo-sterile mouse experiments and fecal microbiota transplantation (FMT). The expression of genes related to the TLR4/NF-κB/NLRP3 pathway was also examined. TUDCA significantly ameliorated cognitive impairments, reduced Aβ accumulation, and suppressed inflammatory responses in both the central nervous system and peripheral tissues. It improved intestinal barrier function and reshaped gut microbial composition…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsGut microbiota and health · Drug Transport and Resistance Mechanisms · Alzheimer's disease research and treatments