# Neurosense: Bridging Neural Dynamics and Mental Health Through Deep Learning for Brain Health Assessment via Reaction Time and p-Factor Prediction

**Authors:** Haipeng Wang, Shanruo Xu, Runkun Guo, Jiang Han, Ming-Chun Huang

PMC · DOI: 10.3390/diagnostics16020293 · Diagnostics · 2026-01-16

## TL;DR

Neurosense uses EEG and deep learning to assess brain health by predicting reaction times and estimating mental health dimensions with high efficiency.

## Contribution

Introduces a dual-path neural architecture and parameter-efficient transfer learning for brain health assessment using EEG data.

## Key findings

- The model effectively predicts reaction time from EEG signals.
- Adapter-based transfer learning outperforms direct training for p-factor prediction while using only 1.7% of parameters.
- Cognitive efficiency representations can be adapted for mental health assessment, revealing neural dynamics' role in psychopathology.

## Abstract

Background/Objectives: Cognitive decline and compromised attention control serve as early indicators of neurodysfunction that manifest as broader psychopathological symptoms, yet conventional mental health assessment relies predominantly on subjective self-report measures lacking objectivity and temporal granularity. We propose Neurosense, an AI-driven brain health assessment framework using electroencephalography (EEG) to non-invasively capture neural dynamics. Methods: Our Dual-path Spatio-Temporal Adaptive Gated Encoder (D-STAGE) architecture processes temporal and spatial EEG features in parallel through Transformer-based and graph convolutional pathways, integrating them via adaptive gating mechanisms. We introduce a two-stage paradigm: first training on cognitive task EEG for reaction time prediction to acquire cognitive performance-related representations, then featuring parameter-efficient adapter-based transfer learning to estimate p-factor—a transdiagnostic psychopathology dimension. The adapter-based transfer achieves competitive performance using only 1.7% of parameters required for full fine-tuning. Results: The model achieves effective reaction time prediction from EEG signals. Transfer learning from cognitive tasks to mental health assessment demonstrates that cognitive efficiency representations can be adapted for p-factor prediction, outperforming direct training approaches while maintaining parameter efficiency. Conclusions: The Neurosense framework reveals hierarchical relationships between neural dynamics, cognitive efficiency, and mental health dimensions, establishing foundations for a promising computational framework for mental health assessment applications.

## Full-text entities

- **Diseases:** Cognitive decline (MESH:D003072), compromised attention control (MESH:D007174)

## Full text

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## Figures

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## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12840185/full.md

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Source: https://tomesphere.com/paper/PMC12840185