# Association Between Frailty and Leptin Levels in Patients with Stable Coronary Artery Disease

## TL;DR

This study found that frail patients with coronary artery disease have higher leptin levels, a hormone linked to fat, compared to non-frail patients.

## Contribution

The study identifies a novel association between frailty and elevated leptin levels in CAD patients before PCI.

## Key findings

- Frail CAD patients had significantly higher leptin levels than non-frail patients.
- There was a moderate inverse correlation between SPPB scores and leptin levels.
- Regression analysis showed SPPB scores and age were associated with high leptin levels.

## Abstract

Background/Objectives: The study aimed to examine the association between the total SPPB score and serum leptin levels in patients with coronary artery disease (CAD) undergoing elective percutaneous coronary intervention (PCI). Methods: A cross-sectional study included 204 prospectively enrolled patients with CAD who were admitted for elective PCI. The mean age was 67.45 ± 8.63 years; 63.2% of patients were male. The Short Physical Performance Battery (SPPB) was used to screen for prefrailty and frailty (10–12 points: no frailty; 8–9 points: prefrailty; ≤7 points: frailty). The levels of leptin, a biomarker of fat remodeling, were measured by a highly sensitive and highly specific enzyme immunoassay using a Diagnostics Biochem Canada Inc. Leptin ELISA Kit (London, ON, Canada). Results: The prevalence of frailty and prefrailty in patients with stable CAD was 20.1% and 40.2%, respectively. A comparative analysis revealed that frailty was significantly more likely in older women with CAD before elective PCI. The total serum leptin level was 13.00 [8.00–50.00] ng/mL. Frail patients with CAD had higher leptin levels than patients without frailty (25.40 [7.00–60.00] ng/mL vs. 12.00 [5.15–19.70] ng/mL, p = 0.037). The leptin level in patients with prefrailty was 16.70 [13.00–49.10] ng/mL. Moreover, there was a moderate inverse correlation between the total SPPB score and serum leptin levels before PCI (p = 0.006). A regression analysis found that the total SPPB score in patients with stable CAD was associated with high serum leptin levels (p < 0.001) and older age (p = 0.017). Conclusions: Our study found that frail patients with CAD undergoing PCI had higher serum leptin levels than patients without frailty.