# The Role of Oxidative Stress and Total Antioxidant Capacity in the Management of Impacted Third Molars: A Narrative Review

## TL;DR

This review explores how oxidative stress and antioxidant levels are affected by impacted third molars and how their surgical removal can help reduce oxidative stress.

## Contribution

The paper provides a narrative review connecting oxidative stress markers and impacted third molars, emphasizing the benefits of surgical removal.

## Key findings

- Oxidative stress biomarkers like MPO, MDA, UA, and NO are elevated in patients with impacted third molars.
- Surgical removal of impacted third molars reduces oxidative stress and improves total antioxidant capacity.
- Oxidative markers return to normal levels shortly after surgery.

## Abstract

Oxidative stress (OS) has gained substantial relevance due to its involvement in the pathogenesis of numerous systemic diseases. It is characterized by an imbalance between the production of reactive oxygen species (ROS) and the capacity of endogenous antioxidant systems to neutralize them. Various factors, including trauma, immunological alterations, and psychological stress, may contribute to this condition. The aim of this narrative review was to analyze OS markers and total antioxidant capacity (TAC) in asymptomatic and pericoronitis-associated impacted mandibular third molars (ITMs). This review examines the relationship between OS and impacted ITMs, highlighting the importance of timely clinical management to prevent chronic tissue damage. Current evidence indicates that OS biomarkers such as myeloperoxidase (MPO), malondialdehyde (MDA), uric acid (UA), and nitric oxide (NO) are elevated in patients with ITMs, including those classified as asymptomatic, and that a reduction in total antioxidant capacity (TAC) has been observed. The surgical removal of ITMs can effectively reduce OS levels. Following the procedure, oxidative markers typically return to normal within a relatively short period of time, and there is often a significant improvement in TAC.