# Paratubal Leiomyoma Mimicking Ovarian Malignancy: A Case Report and Literature Review

**Authors:** Wen-Lin Hsieh, Dah-Ching Ding

PMC · DOI: 10.3390/diagnostics16020218 · Diagnostics · 2026-01-09

## TL;DR

A rare case of a paratubal leiomyoma was mistaken for ovarian cancer, highlighting the need for accurate diagnosis to avoid unnecessary treatment.

## Contribution

This case report adds to the limited literature on paratubal leiomyomas and emphasizes the importance of histopathological confirmation.

## Key findings

- Imaging alone can mislead diagnosis, as the paratubal leiomyoma appeared similar to ovarian malignancy.
- Histopathology confirmed the benign nature of the tumor, preventing overtreatment.
- The patient had no recurrence after 6 months, supporting the effectiveness of the surgical approach.

## Abstract

Background and Clinical Significance: A paratubal leiomyoma is an exceptionally rare benign smooth muscle tumor arising from paratubal tissue, with only sporadic cases reported in the literature. Case Presentation: We present the case of a 72-year-old postmenopausal woman with intermittent spotting for three months. A pelvic examination revealed a retained intrauterine device, which was removed along with an old sanguineous discharge. A transvaginal ultrasound demonstrated a complex left adnexal mass with calcifications, and computed tomography (CT) confirmed a 7.8 × 5.5 × 4.7 cm lesion suggestive of an ovarian malignancy. Tumor markers showed mildly elevated CA-125 and carcinoembryonic antigen (CEA) levels. Endometrial sampling using a hysteroscopy and curettage revealed hyperplasia without atypia. The patient underwent a total laparoscopic hysterectomy with a bilateral salpingo-oophorectomy. A diagnostic laparoscopy revealed a well-circumscribed solid mass arising from the mesosalpinx, separate from the ovary and fallopian tube and consistent with a paratubal mass, which was successfully excised laparoscopically. Frozen sections suggested a fibroma, and the final pathology confirmed a paratubal leiomyoma with hyalinization, accompanied by adenomyosis and simple endometrial hyperplasia. The patient recovered uneventfully, and the 6-month follow-up showed no recurrence. This case highlights the diagnostic challenge of differentiating paratubal leiomyomas from ovarian tumors based on imaging alone. Histopathological examination is essential for confirmation. Conclusions: Awareness of paratubal leiomyomas as a differential diagnosis may prevent overtreatment and guide the appropriate surgical management of postmenopausal women presenting with adnexal masses.

## Linked entities

- **Diseases:** adenomyosis (MONDO:0010888), endometrial hyperplasia (MONDO:0041161)

## Full-text entities

- **Genes:** MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** hyperplasia (MESH:D006965), endometrial hyperplasia (MESH:D004714), Paratubal Leiomyoma (MESH:D007889), Ovarian Malignancy (MESH:D010051), Tumor (MESH:D009369), smooth muscle tumor (MESH:D018235), fibroma (MESH:D005350), calcifications (MESH:D002114), adenomyosis (MESH:D062788), adnexal masses (MESH:D000291)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

76 references — full list in the complete paper: https://tomesphere.com/paper/PMC12839717/full.md

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Source: https://tomesphere.com/paper/PMC12839717