# Bio-RegNet: A Meta-Homeostatic Bayesian Neural Network Framework Integrating Treg-Inspired Immunoregulation and Autophagic Optimization for Adaptive Community Detection and Stable Intelligence

## TL;DR

Bio-RegNet is a new AI framework inspired by biological regulation that improves stability and efficiency in learning.

## Contribution

Introduces a meta-homeostatic Bayesian neural network integrating immunoregulation and autophagy for adaptive intelligence.

## Key findings

- Bio-RegNet outperforms state-of-the-art dynamic GNNs on twelve benchmarks with improved calibration and energy efficiency.
- The model achieves faster recovery from perturbations and enhances ARI and NMI metrics compared to HGNN-ODE.
- It enables seamless transfer between biological and manufactured systems through domain-invariant equilibrium.

## Abstract

Contemporary neural and generative architectures are deficient in self-preservation mechanisms and sustainable stability. In uncertain or noisy situations, they frequently demonstrate oscillatory learning, overconfidence, and structural deterioration, indicating a lack of biological regulatory principles in artificial systems. We present Bio-RegNet, a meta-homeostatic Bayesian neural network architecture that integrates T-regulatory-cell-inspired immunoregulation with autophagic structural optimization. The model integrates three synergistic subsystems: the Bayesian Effector Network (BEN) for uncertainty-aware inference, the Regulatory Immune Network (RIN) for Lyapunov-based inhibitory control, and the Autophagic Optimization Engine (AOE) for energy-efficient regeneration, thereby establishing a closed energy–entropy loop that attains adaptive equilibrium among cognition, regulation, and metabolism. This triadic feedback achieves meta-homeostasis, transforming learning into a process of ongoing self-stabilization instead of static optimization. Bio-RegNet routinely outperforms state-of-the-art dynamic GNNs across twelve neuronal, molecular, and macro-scale benchmarks, enhancing calibration and energy efficiency by over 20% and expediting recovery from perturbations by 14%. Its domain-invariant equilibrium facilitates seamless transfer between biological and manufactured systems, exemplifying a fundamental notion of bio-inspired, self-sustaining intelligence—connecting generative AI and biomimetic design for sustainable, living computation. Bio-RegNet consistently outperforms the strongest baseline HGNN-ODE, improving ARI from 0.77 to 0.81 and NMI from 0.84 to 0.87, while increasing equilibrium coherence κ from 0.86 to 0.93.