# The Mechanism and Regulation of Disulfidptosis and Its Role in Disease

## TL;DR

This review explores disulfidptosis, a new type of cell death involving protein disulfide bonds, and its potential for treating cancer and chronic diseases.

## Contribution

It systematically summarizes the mechanisms, regulation, and therapeutic potential of disulfidptosis.

## Key findings

- Disulfidptosis is characterized by the accumulation of protein disulfide bonds.
- It offers new therapeutic strategies for cancer and chronic diseases.
- The review highlights unresolved issues and future research directions.

## Abstract

Disulfidptosis is a recently identified form of regulatory cell death (RCD), Which has emerged as a research hotspot due to its distinctive feature of accumulating protein disulfide bonds, setting it apart from other RCD mechanisms. This discovery may offer new therapeutic strategies for cancer and various chronic diseases. This review aims to summarize the molecular mechanisms, inhibitors, regulatory networks, distinctions and connections between disulfidptosis and other regulatory death pathways, and the application of disulfidptosis in tumors and other chronic diseases. It also identifies unresolved issues and provides an outlook on future prospects.