# Research Advances and Disease Modeling in Respiratory Organoids

## TL;DR

Respiratory organoids are advanced biological models that improve disease research and drug development by mimicking human respiratory systems more accurately than traditional methods.

## Contribution

This review highlights recent advances in respiratory organoid models and their transformative potential in studying and treating respiratory diseases.

## Key findings

- Respiratory organoids provide human-specific microenvironments for studying disease mechanisms and drug responses.
- They enable functional drug screening and personalized therapy development for respiratory diseases.
- Integration with precision medicine could redefine respiratory disease research.

## Abstract

Organoid culture represents a sophisticated biological model that surpasses traditional two-dimensional (2D) methods and animal models in physiological relevance and cost-effectiveness. Current organoid systems derive from adult, fetal, and induced pluripotent stem cells, providing innovative platforms for studying organ development, disease pathogenesis, and drug discovery. Recent technological advances now enable respiratory organoids to significantly contribute to respiratory disease research. This review comprehensively synthesizes the development of respiratory organoid models and their applications in studying major respiratory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. It further evaluates the transformative potential of these models in advancing respiratory disease research. Respiratory organoids uniquely model disease mechanisms and drug responses in human-specific microenvironments, enabling pathogenesis studies of respiratory diseases. They serve as functional platforms for drug screening and personalized therapy development. Future integration of multi-organoid systems with precision medicine promises to redefine respiratory disease research paradigms.