# Global and Local Processing of Letters and Faces in Children and Adolescents with Typical and Atypical Development

**Authors:** Silvia Primativo, Roberta Daini, Jennifer Pavia, Elisa Fucà, Floriana Costanzo, Cristina Caciolo, Paolo Alfieri, Deny Menghini, Stefano Vicari, Lisa S. Arduino

PMC · DOI: 10.3390/brainsci16010096 · Brain Sciences · 2026-01-16

## TL;DR

This study explores how children and adolescents with typical development, Down syndrome, and Williams syndrome process visual information globally or locally using letters and schematic faces.

## Contribution

The study identifies distinct global precedence and interference effects across different groups and stimulus types, challenging prior classifications.

## Key findings

- Typically developing children show a global precedence effect for letters but not schematic faces.
- DS and WS groups exhibit a global processing bias for schematic faces and a global interference effect.
- Results suggest cognitive demands and stimulus type influence processing preferences in neurodevelopmental conditions.

## Abstract

Background/Objectives: this paper investigates the local vs. global visual processing preference in typically developing (TD) children, youth with Down syndrome (DS), and youth with Williams syndrome (WS). In particular, the global precedence effect (GPE) and the global interference effect (GI) have recently been described as two distinct and at least partially independent effects. Methods: in this study, 50 participants (TD = 25, DS = 13, WS = 12) completed two experiments requiring the identification of either the global or local level of hierarchical stimuli, which consisted of letters and schematic faces. For each stimulus type, two separate blocks were conducted, one with the task to focus on the local elements and the other with the task to focus on the global shape. Results: our results indicate that TD children demonstrate a global precedence effect for letters but not for schematic faces, suggesting a developmental modulation of configural processing. In contrast, both DS and WS groups showed a global processing bias for schematic faces and a significant global interference effect in both conditions, likely reflecting deficits in inhibitory control. Conclusions: these findings challenge the notion that DS and WS individuals can be classified strictly as global or local processors, respectively, emphasizing the influence of stimulus type and cognitive demands. Implications for neurodevelopmental research and clinical interventions are discussed.

## Linked entities

- **Diseases:** Down syndrome (MONDO:0008608), Williams syndrome (MONDO:0008678)

## Full-text entities

- **Diseases:** WS (MESH:D018980), DS (MESH:D004314)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12838541/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12838541/full.md

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Source: https://tomesphere.com/paper/PMC12838541