# Periodontal Bacteria and Outcomes Following Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Analysis

## TL;DR

This study found that severe gum disease and related bacteria may increase the risk of brain complications after a type of stroke called aneurysmal subarachnoid hemorrhage.

## Contribution

The study is the first to link periodontal pathogens and inflammation markers to delayed cerebral ischemia outcomes in aSAH patients.

## Key findings

- Periodontal pocket depth ≥ 5 mm was significantly associated with delayed cerebral ischemia (DCI).
- Certain periodontal pathogens correlated with higher inflammation markers (hsCRP, IL-6) in aSAH patients.
- Systemic inflammation from periodontal disease may contribute to DCI risk after aneurysmal subarachnoid hemorrhage.

## Abstract

Background: Periodontitis has been associated with systemic diseases such as cerebrovascular events. Emerging research highlights the potential role of the microbiome in intracranial aneurysm formation and rupture. Aims: We aimed to explore the associations among periodontal pathogens and the outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Materials and Methods: A total of 43 aSAH patients were enrolled. Clinical probing depth measurement and microbiological culture were performed for all participants. The markers of systemic immune response (IL-6, hsCRP) and brain injury (NSE, S100B) were measured between 24 and 48 h after admission. Development of delayed cerebral ischemia (DCI) as the primary and clinical outcome, based on modified Rankin Scale as secondary endpoints, comprised the chosen metrics. Results: A significant association was observed between patients with periodontal pocket depth PPD ≥ 5 mm (n = 28) and DCI, which developed in 19 patients (p = 0.007). In the subgroup of patients with PPD ≥ 5 mm significant associations were found between certain periodontal pathogens and DCI. Higher hsCRP (p = 0.05), IL-6 (p = 0.037) levels were observed in cases with periodontal pathogens, independent of the depth of the pocket, suggesting systemic inflammation. Conclusions: Elevated hsCRP and IL-6 levels, periodontal pocket depth ≥ 5 mm, and red-complex periodontal pathogens are associated with an increased risk of DCI after aSAH, suggesting a role for periodontal disease–related systemic inflammation in DCI risk stratification.