# Generative Adversarial Networks for Modeling Bio-Electric Fields in Medicine: A Review of EEG, ECG, EMG, and EOG Applications

**Authors:** Jiaqi Liang, Yuheng Zhou, Kai Ma, Yifan Jia, Yadan Zhang, Bangcheng Han, Min Xiang

PMC · DOI: 10.3390/bioengineering13010084 · Bioengineering · 2026-01-12

## TL;DR

This paper reviews how GANs can improve modeling of bio-electric signals like EEG and ECG for better medical diagnostics.

## Contribution

A comprehensive survey of GAN applications in bio-electric signal processing with a focus on clinical and emerging uses.

## Key findings

- GANs effectively address data imbalance and noise in bio-electric signal modeling.
- Applications include signal synthesis, noise reduction, and anomaly detection for conditions like epilepsy and arrhythmia.
- Emerging uses in BCI and signal reconstruction highlight GANs' versatility in medical contexts.

## Abstract

Bio-electric fields—manifested as Electroencephalogram (EEG), Electrocardiogram (ECG), Electromyogram (EMG), and Electrooculogram (EOG)—are fundamental to modern medical diagnostics but often suffer from severe data imbalance, scarcity, and environmental noise. Generative Adversarial Networks (GANs) offer a powerful, nonlinear solution to these modeling hurdles. This review presents a comprehensive survey of GAN methodologies specifically tailored for bio-electric signal processing. We first establish a theoretical foundation by detailing GAN principles, training mechanisms, and critical structural variants, including advancements in loss functions and conditional architectures. Subsequently, the paper extensively analyzes applications ranging from high-fidelity signal synthesis and noise reduction to multi-class classification. Special attention is given to clinical anomaly detection, specifically covering epilepsy, arrhythmia, depression, and sleep apnea. Furthermore, we explore emerging applications such as modal transformation, Brain–Computer Interfaces (BCI), de-identification for privacy, and signal reconstruction. Finally, we critically evaluate the computational trade-offs and stability issues inherent in current models. The study concludes by delineating prospective research avenues, emphasizing the necessity of interdisciplinary synergy to advance personalized medicine and intelligent diagnostic systems.

## Linked entities

- **Diseases:** epilepsy (MONDO:0005027), arrhythmia (MONDO:0007263), depression (MONDO:0002050), sleep apnea (MONDO:0005296)

## Full-text entities

- **Diseases:** sleep apnea (MESH:D012891), depression (MESH:D003866), arrhythmia (MESH:D001145), epilepsy (MESH:D004827)
- **Chemicals:** GAN (-)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12837272/full.md

## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12837272/full.md

## References

159 references — full list in the complete paper: https://tomesphere.com/paper/PMC12837272/full.md

---
Source: https://tomesphere.com/paper/PMC12837272