# A Randomized, Double-Blind, Contralateral Eye Study Comparing the Clinical Outcomes of Two Types of Silicone Hydrogel Bandage Contact Lenses After Transepithelial Photorefractive Keratectomy

## TL;DR

This study compares two types of contact lenses after eye surgery, finding one reduces pain and protein buildup better.

## Contribution

The study introduces a direct comparison of two silicone hydrogel bandage contact lenses after TPRK, focusing on pain and protein deposition.

## Key findings

- Lotrafilcon A reduced postoperative pain scores compared to Balafilcon A.
- Lotrafilcon A showed significantly less protein deposition on the lenses.
- No significant differences were found in visual acuity or epithelial healing between the two lenses.

## Abstract

Background: To compare clinical outcomes of Lotrafilcon A and Balafilcon A silicone hydrogel bandage contact lenses (BCLs) following transepithelial photorefractive keratectomy (TPRK). Methods: A randomized, double-blind, contralateral eye study enrolled 41 TPRK patients (82 eyes), with each eye randomly assigned one BCL type. Assessments included uncorrected (UDVA) and corrected (CDVA) distance visual acuity, ocular pain and irritation, epithelial healing, limbal and conjunctival hyperemia, lens mobility, and the amount of protein deposition on the BCLs. Results: Postoperative day 1 pain score was lower in Group A (2.80 ± 2.35) than in Group B (4.44 ± 2.46, p = 0.003). Group A had significantly less protein deposition (day 3: 9.92 ± 9.82 vs. 25.75 ± 9.86 μg, p < 0.001; day 4: 9.47 ± 10.06 vs. 32.60 ± 16.71 μg, p = 0.005). No statistically significant differences were observed between the two groups in terms of corneal epithelial defect area, corneal epithelial healing time, UDVA, CDVA, limbal or conjunctival hyperemia, and lens movement. Conclusions: Lotrafilcon A outperformed Balafilcon A in reducing ocular pain, foreign body sensation, and protein deposition, suggesting that Lotrafilcon A may be a more suitable therapeutic BCL option following TPRK.