# A CLIP on the Ear: Spitz Melanocytoma Harbouring a CLIP2-BRAF Gene Fusion

## TL;DR

This paper reports a rare case of a spitzoid melanocytoma with a CLIP2-BRAF gene fusion, challenging the assumption that BRAF mutations are incompatible with Spitz tumors.

## Contribution

The novel contribution is the identification of a rare CLIP2-BRAF gene fusion in a spitzoid melanocytoma.

## Key findings

- A spitzoid melanocytoma was found to harbor a CLIP2-BRAF gene fusion.
- This finding challenges the conventional view that BRAF mutations are incompatible with Spitz tumors.

## Abstract

Spitzoid lesions represent one of the most challenging areas in melanocytic pathology. Many such lesions are characterised by key gene alterations including ALK, ROS and NTRK fusions. BRAF mutations are generally considered incompatible with the diagnosis of Spitz tumours. Here, we present the case of a spitzoid melanocytoma harbouring a rare BRAF gene fusion. A brief overview of the literature is also touched upon.