# Exploring huntington's disease from a neurodevelopmental perspective

## TL;DR

This paper explores Huntington's disease from a new angle, focusing on how developmental issues might contribute to the disease, not just degeneration.

## Contribution

The paper introduces a novel perspective on HD by emphasizing the role of neurodevelopmental effects of mutant HTT.

## Key findings

- HTT plays a crucial role in normal neurodevelopment.
- Mutant HTT affects neurodevelopment in various models.
- Early intervention during development may improve HD outcomes.

## Abstract

Huntington's disease (HD) is a rare, inherited neurodegenerative disorder caused by mutations in the huntingtin (HTT) gene. The classic concept is that HD is a degenerative disease that primarily affects the striatum, caused by a gain-of-function mutant mHTT that kills neurons. However, increasing evidence suggests that the effects of mHTT on development may be an alternative view of HD. Therefore, we describe the importance of HTT for neurodevelopment and then summarize the effects of mHTT on neurodevelopment that have been revealed so far in different models. Importantly, we provide new insights into the use of different models to study HD development, and propose new therapeutic strategies for intervening in HD early in development to improve disease progression. Furthermore, we explore potential connections between neurodevelopmental abnormalities and neurodegenerative processes in HD. This review provides a systematic synthesis of current knowledge regarding HD development and pathogenesis.