# Deep transfer learning and explainable AI framework for autism spectrum disorder detection across multiple datasets

**Authors:** Shtwai Alsubai

PMC · DOI: 10.3389/fneur.2025.1617446 · 2026-01-13

## TL;DR

This paper introduces a transfer learning framework using deep neural networks to detect autism spectrum disorder across different datasets, showing improved performance and insights into key features.

## Contribution

The novel contribution is a transfer learning approach with explainable AI for ASD detection across diverse datasets, revealing common behavioral indicators.

## Key findings

- The DNN architecture outperformed LSTM and Attention LSTM models in ASD detection.
- Transfer learning improved performance with limited training data across different datasets.
- Explainable AI techniques identified key features for ASD classification across populations.

## Abstract

This paper presents a transfer learning approach for Autism Spectrum Disorder (ASD) detection using Deep Neural Networks (DNN) across three distinct datasets.

A baseline was established by training multiple machine learning and deep learning models on a toddler ASD screening dataset from Saudi Arabia, augmented with the Synthetic Minority Oversampling Technique (SMOTE) to address class imbalance. The DNN architecture featured regularization and dropout layers. The trained model was then leveraged by transferring learned knowledge to two additional ASD datasets. Model performance was analyzed through standard metrics and explainable AI techniques.

The DNN architecture outperformed other models (i.e., LSTM and Attention LSTM). Transfer learning demonstrated improved performance with limited training data. Explainable AI techniques provided insights into key features for ASD classification across different populations.

Results indicate the efficacy of transfer learning for cross-dataset ASD classification, suggesting the presence of common behavioral indicators despite demographic and data collection differences.

## Linked entities

- **Diseases:** Autism Spectrum Disorder (MONDO:0005258)

## Full-text entities

- **Diseases:** ASD (MESH:D000067877)

## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12836383/full.md

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Source: https://tomesphere.com/paper/PMC12836383