Comparison of clinical indicators between perimenopausal and postmenopausal women with cardiovascular disease

TL;DR

This study compares health indicators in perimenopausal and postmenopausal women with cardiovascular disease to understand how menopause affects CVD risk.

Contribution

The study identifies specific clinical differences between perimenopausal and postmenopausal women with CVD, highlighting hormonal and metabolic changes.

Findings

Postmenopausal women showed higher BMI, blood pressure, and hormone levels compared to perimenopausal women.

Significant differences in obesity indicators and bone mineral density were found between age groups.

Hormonal changes during menopause are linked to increased cardiovascular disease risk.

Abstract

Cardiovascular disease (CVD) prevalence increases with age, particularly in perimenopausal and postmenopausal women due to declining estrogen levels increasing CVD risk.

From 1248 women, 276 with CVD were screened. Clinical indicators (obesity, blood pressure, BMD, hormones) were compared between perimenopausal and postmenopausal women and across age groups (40-44, 45-49, 50-54). Postmenopausal women had significantly higher BMI, WC/HC, BFP, BFD, SBP, DBP, E2, P, PRL (p < 0.001), but lower FSH, LH, BMD T1/T2 (p < 0.001) than perimenopausal women. Significant differences in obesity indicators, BMD, and hormones existed between the 45–49 and 50–54 age groups (p < 0.05).

This study elucidates how hormonal changes affect CVD development in women, providing a basis for early screening and intervention strategies.

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