# Childhood adversities and post-traumatic stress: predictive pathways through acute stress disorder

**Authors:** Josleen Al Barathie, Majd Chamoun, Rayane Osman, Elie G. Karam

PMC · DOI: 10.1192/bjo.2025.10948 · 2026-01-16

## TL;DR

The study shows that childhood emotional abuse increases the risk of developing stress-related mental health disorders after a traumatic event.

## Contribution

The study identifies emotional abuse in childhood as a strong predictor of both acute stress disorder and PTSD following trauma.

## Key findings

- Emotional abuse in childhood significantly predicts acute stress disorder and PTSD onset after trauma.
- Individuals with childhood emotional abuse had double the rates of subthreshold PTSD despite not having acute stress disorder initially.

## Abstract

Trauma, a psychological phenomenon, can contribute to several mental health disorders such as acute stress disorder (ASD) and post-traumatic stress disorder (PTSD). Understanding the impacts of childhood adversities on mental disorders is essential, since early trauma can profoundly shape an individual’s reaction to subsequent trauma.

To study the association between childhood adversities and full-threshold and subthreshold PTSD onset, either directly or through the intermediary role of ASD.

Data were collected longitudinally from healthcare workers aged 18 years and above, working at Saint George Hospital University Medical Center, at three distinct time points: 9–15 days (wave 1), 21–27 days (wave 2) and 6–7 months (wave 3) following the Beirut port blast on 4 August 2020.

Childhood adversities, encompassing physical, emotional and sexual abuse, were collected. ASD and PTSD were assessed, respectively, using the Acute Stress Disorder Scale and the PTSD Checklist for DSM-5. Odds ratios, both unadjusted and adjusted, with 95% confidence intervals, were calculated to study the associations.

Emotional abuse was found to be a significant predictor of ASD at wave 2 (21–27 days), and both full-threshold and subthreshold PTSD at wave 3 (6–7 months) post-blast. Individuals with negative ASD status at waves 1 and 2 who experienced emotional abuse in childhood showed approximately double the rates of subthreshold PTSD.

Childhood emotional abuse was a strong predictor of both ASD and PTSD. Screening for past childhood adversities is important, even in individuals without ASD, as they remain more vulnerable to later PTSD.

## Linked entities

- **Diseases:** acute stress disorder (MONDO:0003763), post-traumatic stress disorder (MONDO:0005146)

## Full-text entities

- **Genes:** AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}
- **Diseases:** anxiety (MESH:D001007), Mental (MESH:D008607), sexual violence (MESH:D050035), psychological maltreatment (MESH:D000067073), negative mood (MESH:D019964), Stress Disorder (MESH:D000079225), burnout (MESH:D002055), dissociation (MESH:D004213), ASD (MESH:D040701), alcohol or drug misuse (MESH:D009293), anhedonia (MESH:D059445), Trauma (MESH:D014947), trauma-related disorders (MESH:D000068099), emotional maltreatment (MESH:D003072), death (MESH:D003643), intrusion (MESH:C537310), depressed (MESH:D003866), COVID-19 (MESH:D000086382), childhood abuse/neglect (MESH:D058069), Childhood adversity (MESH:D064420), Emotional abuse (MESH:D019966), dysphoria (MESH:D019052), blast (MESH:D001753), PTSD (MESH:D013313), aggression (MESH:D010554), physical and sexual abuse (MESH:D000082002), mental health disorders (OMIM:603663), mental disorders (MESH:D001523), Traumatic Stress (MESH:D040921)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12835713/full.md

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Source: https://tomesphere.com/paper/PMC12835713