# Real-world comparison of mechanical thrombectomy vs. catheter-directed thrombolysis for the treatment of pulmonary embolism: a single-center retrospective study

## TL;DR

This study compares mechanical thrombectomy and catheter-directed thrombolysis for treating pulmonary embolism in real-world clinical practice.

## Contribution

The study evaluates real-world outcomes without using a composite endpoint, using a large sample size.

## Key findings

- No significant difference in 7-day or 30-day mortality between the two treatments.
- FTMT showed significantly less risk of procedure-related decompensations.
- ICU length of stay was shorter for FTMT, but total hospital stay was longer.

## Abstract

A recent multi-site randomized controlled trial, PEERLESS, demonstrated superiority of FlowTriever mechanical thrombectomy (FTMT) to catheter-directed thrombolysis (CDT) in the treatment of intermediate-risk pulmonary embolism using a 5-point composite outcome. The purpose of our study is to review clinical outcomes between these two procedures in actual clinical practice without the use of a composite endpoint using a large sample size. This is a retrospective, single-center analysis of 461 patients who presented with submassive or massive PE and underwent treatment with either FTMT or CDT. No significant difference was observed in 7-day (RR 0.495; p = 0.25) or 30-day mortality (RR 1.347; p = 0.67). There was significantly less risk of procedure-related decompensations within the FTMT group (RR 0.221; p = 0.01). Non-procedure-related decompensations were similar between treatment options (RR 1.091; p = 0.51). ICU LOS was significantly lower for FTMT (mean 1.87 vs. 3.07; p < 0.001) however total LOS was longer within the FTMT (mean 6.85 vs. 5.68; p = 0.008). Similar to PEERLESS, we observed decreased ICU utilization with FTMT in our real-world retrospective data, likely reflecting our practice of ICU admission during thrombolytic administration. We observed slightly lower risk of procedure-related decompensations within the FTMT group, suggesting lower periprocedural morbidity; however, overall mortality between groups was not different.