# Differentiating vestibular migraine from Meniere's disease: an analysis of clinical features, videonystagmography, and caloric testing

**Authors:** Xueyan Zhang, Qirong Wang, Jiao Xu, Tao Zhou, Jin Xu, Zheng Liu, Xu Yang, Huaying Cai, Wencheng Luo, Mei Hu, Liying Chang

PMC · DOI: 10.3389/fnins.2025.1745820 · 2026-01-13

## TL;DR

This study compares clinical features and tests to distinguish vestibular migraine from Meniere's disease, finding that caloric testing is a reliable and cost-effective diagnostic tool.

## Contribution

The study identifies caloric testing as a practical method to differentiate vestibular migraine from Meniere's disease.

## Key findings

- The caloric test showed significantly higher canal paresis in Meniere's disease patients compared to vestibular migraine patients.
- Clinical symptom profiles are effective in distinguishing between the two disorders.
- Interictal nystagmus analysis has limited diagnostic value for differentiating the conditions.

## Abstract

Vestibular migraine (VM) and Meniere's disease (MD) are episodic vertigo disorders with overlapping symptoms, often leading to misdiagnosis. This study aimed to identify a cost-effective diagnostic method to distinguish VM and MD.

In this retrospective study, 108 VM patients and 65 MD patients were enrolled. Clinical symptoms, interictal videonystagmography (VNG) findings, and caloric test results were analyzed and compared between the two groups.

The VM group had a significantly higher proportion of females (p < 0.001). No significant differences were observed in any features of interictal nystagmus, including spontaneous or positional nystagmus (all p > 0.05). However, the caloric test revealed a significantly higher proportion of canal paresis (CP) in MD patients compared to VM patients (p < 0.001).

While clinical symptom profiles effectively distinguish VM from MD, interictal nystagmus analysis has limited diagnostic value. The caloric test is a reliable and practical tool, as the presence of significant canal paresis strongly indicates MD over VM. Combining symptom evaluation with caloric testing offers a cost-effective strategy for the differential diagnosis of these common vestibular disorders.

## Full-text entities

- **Diseases:** MD (MESH:D008575), VM (MESH:D008881), episodic vertigo disorders (MESH:D020338), nystagmus (MESH:D009759), vestibular disorders (MESH:D015837), CP (MESH:D010291)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12835259/full.md

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Source: https://tomesphere.com/paper/PMC12835259