# Update of the sequential organ failure assessment score: current status and challenges?

**Authors:** Jiafei Yu, Kangwei Sun, Yiping Zhou, Yushi Fan, Xinyun Zhang, Heyu Chen, Lanxin Cao, Kai Zhang, Gensheng Zhang

PMC · DOI: 10.3389/fmed.2025.1733090 · 2026-01-13

## TL;DR

This paper reviews the limitations of the SOFA score and suggests ways to improve it for better clinical use.

## Contribution

The paper provides a synthesis of recent advances and identifies deficiencies in the SOFA score requiring refinement.

## Key findings

- The SOFA score has limitations that need addressing due to advancements in medical science.
- Recent studies highlight deficiencies in the SOFA score's clinical utility.
- The paper offers a scientific basis for modifying the SOFA score.

## Abstract

The sequential organ failure assessment (SOFA) score has been widely used for approximately 30 years for the clinical assessment and monitoring of organ dysfunction in patients. However, advancements in medical science and clinical practice have identified several limitations of the SOFA score, underscoring the need for its revision. This paper synthesizes and summarizes the recent advances and provides a comprehensive understanding of the deficiencies of the SOFA score, which requires certain refinements. Furthermore, this work presents a scientific basis and direction for further modifications to enhance the clinical utility of the score.

## Full-text entities

- **Diseases:** organ dysfunction (MESH:D009102)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12835212/full.md

---
Source: https://tomesphere.com/paper/PMC12835212