FT3 Levels and Systemic Inflammation: Evidence From a Population‐Based NHANES Analysis
Liu Yang, Han-yu Wang, Meng-fei Fu, Yu-han Zhang, Xiao Chen, Zi-xuan Wang, Hui Sun
TL;DR
This study finds that higher free T3 hormone levels are linked to lower inflammation in the general US population, especially in older adults.
Contribution
The study provides population-based evidence of an inverse relationship between FT3 and systemic inflammation markers.
Findings
FT3 levels were significantly negatively associated with CRP, NLR, and PLR after adjusting for confounders.
Age modified the associations between FT3 and inflammatory markers like CRP, NLR, MLR, SII, and SIRI.
Inverse associations were stronger in individuals aged ≥65 years.
Abstract
Previous studies suggest a complex interaction between 3,3′,5‐triiodo‐L‐thyronine (T3) and inflammation, but this relationship remains unclear. This study investigates the association between free triiodothyronine (FT3) levels and inflammatory markers in the US population using National Health and Nutrition Examination Survey (NHANES) data. This study analyzed NHANES data from three cycles between 2007 and 2012, using Spearman correlation tests and multivariate linear regression. Subgroup analyses and interaction tests were conducted based on age, gender, race, body mass index (BMI), thyroid‐stimulating hormone, and free thyroxine (T4) to determine the correlations between FT3 and seven systemic inflammatory markers: C‐reactive protein (CRP), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐white blood cell ratio (PWR), platelet‐to‐lymphocyte ratio (PLR), monocyte‐to‐lymphocyte ratio…
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Taxonomy
TopicsThyroid Disorders and Treatments · Folate and B Vitamins Research · Pharmacogenetics and Drug Metabolism