# Exercise-induced hypertension, atherogenic lipid subfractions, and cardiorespiratory fitness in marathon runners

## TL;DR

This study found that high blood pressure during exercise in marathon runners is not linked to harmful cholesterol types, but better fitness is associated with healthier cholesterol profiles.

## Contribution

The study is the first to show that exercise-induced hypertension in marathon runners does not correlate with atherogenic lipid subfractions, while higher fitness is linked to better lipid profiles.

## Key findings

- Exercise-induced hypertension was not associated with atherogenic lipid subfractions in marathon runners.
- Higher cardiorespiratory fitness correlated with lower small dense LDL and triglycerides, and higher HDL-cholesterol.
- Exercise-induced hypertension may increase cardiovascular risk through non-lipid pathways.

## Abstract

Exercise-induced hypertension (EIH), defined by an exaggerated exercise systolic blood pressure response, has been linked to cardiovascular events. This study examined whether EIH is associated with atherogenic lipid subfractions and whether cardiorespiratory fitness (CRF) relates to lipid particle characteristics in male marathon runners.

In this cross-sectional study, 51 male marathon runners aged 40–65 years were tested between March and September 2023 at the Exercise Physiology Laboratory, Sungshin Women's University, Seoul, South Korea. Participants were classified as having EIH (n = 29, maximal systolic blood pressure ≥ 210 mmHg) or a normal response (n = 22). Lipid subfractions, including small dense low-density lipoprotein (LDL), were assessed by polyacrylamide gel electrophoresis, and CRF was measured by maximal oxygen uptake (VO₂max).

Lipid subfractions did not differ between EIH and normotensive runners, including small dense LDL and mean LDL particle size (all p > 0.05). Higher VO₂max was associated with lower small dense LDL (r = −0.41, p < 0.01) and triglycerides (r = −0.36, p < 0.01), and higher HDL-cholesterol (r = 0.33, p = 0.02) and mean LDL particle size (r = 0.39, p < 0.01).

Among male marathon runners, EIH was not associated with adverse atherogenic lipid subfractions, whereas higher CRF correlated with more favorable lipid particle profiles, suggesting fitness-related metabolic adaptations may mitigate lipid-mediated cardiovascular risk.

•Exercise-induced hypertension was not linked to harmful lipid subfractions.•Higher fitness levels were associated with more favorable blood lipid patterns.•Runners with higher fitness showed much lower atherogenic lipid phenotype risk.•Exercise-induced hypertension may increase organ risk through non-lipid pathways.

Exercise-induced hypertension was not linked to harmful lipid subfractions.

Higher fitness levels were associated with more favorable blood lipid patterns.

Runners with higher fitness showed much lower atherogenic lipid phenotype risk.

Exercise-induced hypertension may increase organ risk through non-lipid pathways.