# Kounis Syndrome: An Entity One Should Not Forget

**Authors:** Joana Paulo, Daniela Marto, Filipa Figueiredo, Jéssica Oliveira, Mariana Costa

PMC · DOI: 10.7759/cureus.100128 · Cureus · 2025-12-26

## TL;DR

Kounis syndrome is a rare but important condition where allergic reactions can cause heart issues, and it's crucial to recognize it for proper treatment.

## Contribution

The paper highlights the importance of recognizing Kounis syndrome, especially in patients with known drug allergies.

## Key findings

- A patient with drug allergies developed symptoms of Kounis syndrome after taking a painkiller.
- The case demonstrates the acute coronary syndrome triggered by an allergic reaction.
- Kounis syndrome can present with hypotension, syncope, and ECG changes.

## Abstract

Kounis syndrome is an underreported diagnosis, even though it is a frequent pathology. It is an acute coronary syndrome that can present in the setting of an allergic or an anaphylactic reaction that could be triggered by the use of drugs. We present the case of a patient with a known medical history of drug allergies (but not of anaphylaxis), who presented to the emergency department with complaints of headache. After the administration of a painkiller, she developed hypotension, syncope, elevation of troponin, and transitory changes in the ST segment of the electrocardiogram.

## Linked entities

- **Diseases:** anaphylaxis (MONDO:0100053)

## Full-text entities

- **Diseases:** hypotension (MESH:D007022), Kounis Syndrome (MESH:D000074962), acute coronary syndrome (MESH:D054058), syncope (MESH:D013575), drug allergies (MESH:D004342), headache (MESH:D006261), anaphylactic reaction (MESH:D000707)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12834002/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12834002/full.md

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Source: https://tomesphere.com/paper/PMC12834002