# Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals

## TL;DR

A new method allows for adaptive chiral recognition in porous crystals by grafting amino acid-derived moieties, improving enantioselectivity.

## Contribution

A modular click chemistry strategy enables adaptive chiral recognition in porous crystals through post-synthetic grafting.

## Key findings

- Histidine-functionalized UiO-68 frameworks show high enantioselectivity for cetirizine.
- Simulations show adaptive interaction pockets formed by local pore reorganization.

## Abstract

Reticular frameworks are promising candidates for chiral
environments,
yet most rely on static stereogenic units, overlooking adaptive host–guest
interactions in enantioselective recognition. We report a modular
postsynthetic click strategy to install amino acid-derived peptidic
moieties into UiO-68 frameworks without compromising crystallinity.
Only the histidine-functionalized material exhibits high enantioselectivity
for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing
the importance of local pore reorganization in chiral molecular recognition.