# Recurrence of Acne inversa of the penis – two-stage reconstruction with MatriDerm® and split-thickness skin graft

**Authors:** Antek Nicklas, Vlad Stefan, Adrian Dragu

PMC · DOI: 10.3205/iprs000193 · GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW · 2025-12-22

## TL;DR

A 42-year-old man with recurring penile acne inversa was successfully treated using MatriDerm® and a skin graft, leading to long-term improvement and high satisfaction.

## Contribution

This case study demonstrates a successful two-stage reconstructive approach using MatriDerm® and skin graft for penile acne inversa recurrence.

## Key findings

- The patient showed a very good functional and cosmetic outcome after 19 months.
- The patient's quality of life significantly improved from 3.2 to 9.3 on the numeric analog scale.
- The treatment achieved a recurrence-free status in the genital area.

## Abstract

The authors report a case of a 42-year-old male patient who presented with a relapse of penile acne inversa five years after a split-thickness skin graft without use of collagen-elastin-matrix (CEM). After unsatisfactory pharmacological treatment, resection of the affected skin, negative pressure wound therapy (NPWT), CEM application, and split-thickness skin graft (STSG) were performed in several steps.

We performed initial debridement and consecutive NPWT. After achieving a clean wound bed, a CEM (1 mm MatriDerm®; MedSkin Solutions Dr. Suwelack AG, Germany) was applied, followed by split-thickness skin grafting.

During a 19-month follow-up, the patient presented with a very good functional and cosmetic outcome. Under intravenous antibiotic therapy and intensive wound care, we achieved complete recurrence-free status in the genital area at the 19-month follow-up. The subjective quality of life almost tripled from 3.2 to 9.3 on the numeric analog scale (NAS).

Complex reconstruction procedures of penile defects in acne inversa can be avoided if there is a well-perfused wound bed. Coverage of the defect with MatriDerm® and split-thickness skin grafting may lead to long-term aesthetically satisfactory results with high patient satisfaction. We have monitored one patient over 19 months, who presented with stable penile soft tissue coverage and no signs of relapse. We anticipate that coverage of penile defects using MatriDerm® and split-thickness skin grafts may prevent or at least delay the need for complex reconstruction in cases of recurrence.

## Linked entities

- **Diseases:** acne inversa (MONDO:0006559)

## Full-text entities

- **Genes:** ELN (elastin) [NCBI Gene 2006] {aka ADCL1, SVAS, WBS, WS}
- **Diseases:** Acne inversa of the penis (MESH:D017497), penile defects (MESH:D010409)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12833724/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12833724/full.md

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Source: https://tomesphere.com/paper/PMC12833724