# Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and oxidative stress

## TL;DR

Cinnamomum verum extract may help treat atopic dermatitis by reducing oxidative stress and inflammation.

## Contribution

The study demonstrates the therapeutic potential of Cinnamomum verum extract in atopic dermatitis through its antioxidant and anti-inflammatory effects.

## Key findings

- CVE treatment significantly reduced 4-HNE levels in an AD model.
- CVE decreased pro-inflammatory cytokine expression and restored antioxidant enzyme activity.

## Abstract

Oxidative stress and lipid peroxidation play crucial roles in the pathogenesis of atopic dermatitis (AD). Among the by-products of lipid peroxidation, 4-hydroxynonenal (4-HNE) is known to exacerbate inflammatory responses.

This study investigated the potential of Cinnamomum verum J. Presl. [Lauraceae] extract (CVE) in mitigating oxidative stress and suppressing 4-HNE–mediated inflammatory pathways in an AD model. The antioxidant properties of CVE were evaluated through lipid peroxidation assays, reactive oxygen species (ROS) measurement, and cytokine profiling.

CVE treatment significantly reduced 4-HNE levels, decreased pro-inflammatory cytokine expression, and restored antioxidant enzyme activity.

These findings suggest that CVE may serve as a natural therapeutic agent for managing oxidative stress and inflammation in AD.