# Structure and function of neurovascular unit in arterial hypertension

## TL;DR

This review discusses how chronic high blood pressure affects the brain's microcirculation and disrupts the neurovascular unit, leading to cognitive issues.

## Contribution

The paper reviews the structural and functional changes in the neurovascular unit caused by chronic arterial hypertension.

## Key findings

- Chronic hypertension causes endothelial dysfunction and blood-brain barrier disruption.
- Impairment of neurovascular coupling leads to inadequate functional hyperemia.
- Changes in the neurovascular unit components like endothelial cells and astrocytes are discussed.

## Abstract

Arterial hypertension is considered a main risk factor for cognitive impairment and stroke. Although chronic hypertension leads to adaptive changes in the lager cerebral blood vessels which should protect the downstream microvessels, profound changes in the structure and function of cerebral microcirculation were reported in this disease. The structural changes lead to dysregulation of the neurovascular unit and manifest themselves in particular as endothelial dysfunction, disruption of the blood-brain barrier and impairment of neurovascular coupling. The impairment of neurovascular coupling results in inadequate functional hyperemia, which in turn may lead to cognitive decline and dementia. In this review the effects of chronic arterial hypertension on the essential components of neurovascular unit involved in neurovascular coupling such as endothelial cells, astrocytes and pericytes are discussed.