# Endodontic bioceramics: current and futurity aspects

**Authors:** Roma M, Karthik Shetty, Laxmish Mallya, Krishna Prasad Shetty

PMC · DOI: 10.3389/froh.2025.1699547 · Frontiers in Oral Health · 2026-01-12

## TL;DR

This review explores current and future uses of bioceramics in endodontics, focusing on their potential to improve dental treatments.

## Contribution

The paper provides an updated overview of bioceramics in endodontics and identifies areas for future research to enhance their regenerative capabilities.

## Key findings

- Mineral trioxide aggregate (MTA) is widely used and supported in endodontic treatments.
- New bioceramics like Biodentine and EndoSequence show promise but require more clinical trials.
- Improvements in bioceramics are needed for better antibacterial activity and mechanical properties.

## Abstract

Excellent bioactivity and biocompatibility make bioceramics a popular choice in dentistry, especially in endodontics. The most commonly utilised bioceramic in endodontics is mineral trioxide aggregate (MTA). Several emerging bioceramics showed promise for endodontic treatment. This study discusses bioceramics and their use in endodontic treatments like as root-end filling, root canal therapy, vital pulp therapy, apexification/regenerative endodontic treatment, perforation repair, and root defect repair. The applicable research from 1990 to 2023 was screened using keywords in PubMed and Web of Science. According to current research, MTA in the management of endodontic disease is well supported. New bioceramics including Biodentine, EndoSequence, and calcium-enriched mixes have demonstrated encouraging clinical results, but additional controlled trials must be conducted to establish their use in endodontics. To address endodontic problems, bioceramics must be improved for their biologic activity, including antibacterial activity, mechanical qualities, and reduced setting time and solubility. The purpose of this review is to provide an overview of the state of bioceramic technology and to investigate potential avenues for further investigation to improve its regenerative and therapeutic potential in endodontics. Research Question: What developments and potential uses can enhance the endodontic bioceramic-based therapies' regeneration results?

## Full-text entities

- **Diseases:** root defect (MESH:D011843), endodontic disease (MESH:D011671)
- **Chemicals:** MTA (MESH:C086631), calcium (MESH:D002118), Biodentine (MESH:C506393)

## Full text

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## Figures

13 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12832805/full.md

## References

130 references — full list in the complete paper: https://tomesphere.com/paper/PMC12832805/full.md

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Source: https://tomesphere.com/paper/PMC12832805