# Neuroprotective, eco-friendly iron oxide nanoparticles to alleviate Parkinson’s disease symptoms and improve nursing care

## TL;DR

This study explores eco-friendly iron oxide nanoparticles that may help reduce Parkinson’s disease symptoms and support better nursing care.

## Contribution

The novelty lies in biosynthesizing iron oxide nanoparticles using green chemistry for potential PD treatment.

## Key findings

- IONPs showed spherical morphology and favorable physicochemical properties.
- IONPs improved motor performance and antioxidant levels in a PD mouse model.
- IONPs were non-toxic and reduced dopamine neuron apoptosis.

## Abstract

Parkinson’s disease (PD) involves motor impairment and neurochemical changes, necessitating neuroprotective agents to enhance nursing care outcomes.

Iron oxide nanoparticles (IONPs) were biosynthesized via green chemistry and characterized by TEM, UV-Vis, photoluminescence, XRD, and VSM. Antioxidant activity used DPPH assay; biocompatibility involved MTT and hemolysis assays. Efficacy was tested in an MPTP-induced mouse model of PD, assessing motor function, antioxidant capacity, and dopaminergic neuron protection.

IONPs exhibited spherical morphology (39.0 ± 11.3 nm), zeta potential of −13 mV, and saturation magnetization of 42.32 emu/g. They showed concentration-dependent DPPH scavenging and no significant cytotoxicity or hemolysis up to 10 µg/mL. In vitro, IONPs improved motor performance, boosted antioxidants, and reduced apoptosis in dopamine neurons.

Biosynthesized IONPs offer promise as a complementary PD therapy by mitigating motor deficits and neurochemical damage.