# Eosinophilic Gastrointestinal Disease After Pediatric Organ and Bone Marrow Transplantation

## TL;DR

This study explores how different types of organ and bone marrow transplants in children are linked to specific forms of eosinophilic gastrointestinal disease.

## Contribution

The study identifies a novel association between multivisceral transplants and a specific subtype of EGID (EoE + EoG).

## Key findings

- EoE + EoG was significantly more common in multivisceral transplant recipients compared to liver transplant recipients.
- GER and oral allergy syndrome varied significantly between transplant groups.
- No significant differences were found in symptoms, histologic features, or medication responses across transplant types.

## Abstract

Previous studies have shown an increased prevalence of eosinophilic gastrointestinal disease (EGID) in pediatric liver and heart transplant recipients. However, EGID after other solid organ and bone marrow transplantations has not been extensively evaluated.

The purpose of this study is to determine relationships between subsets of EGID with different solid organ and bone marrow transplants in pediatric patients.

We performed a single‐center retrospective chart review of pediatric patients with transplant and EGID between 2007 and 2023. For comparison between transplant groups, ANOVA was used for statistical analysis of continuous variables, and Fisher's exact test was used for categorical variables.

There were 30 patients with EGID (eosinophilic esophagitis [EoE] = 21; eosinophilic gastritis [EoG] = 4; EoE + EoG = 3; EoE + eosinophilic colitis [EoC] = 1; eosinophilic duodenitis [EoD] = 1) and history of transplant (liver = 15; heart = 9; bone marrow = 3; multivisceral liver + small bowel + pancreas = 2; kidney = 1). When comparing the transplant groups, there was a significant difference in EoE + EoG incidence (p = 0.011), specifically, EoE + EoG was present in 2 (100%) multivisceral and in 1/15 (7%) liver transplant patients. A statistically significant difference in the presence of gastroesophageal reflux (GER) and oral allergy syndrome between groups was noted (p = 0.036, p = 0.033). There was no significant difference in the symptoms leading to EGID work‐up: incidence; morphologic features; achievement of histologic remission; medications; or family history of atopy between groups.

This retrospective biopsy‐confirmed cohort demonstrates that EGID subtype varies by transplant type, with higher rates of EoE + EoG in multivisceral recipients. Findings are exploratory and hypothesis‐generating; larger multicenter studies including more non‐liver and non‐heart transplant patients are needed.