# Male occult breast cancer with features highly resembling primary lung cancer: a case report and literature review

**Authors:** Hao Su, Xinyu Zhao, Huayu Liu, Huantong Shu, Wenjing Li, Zhimin Yang, Mianli Li

PMC · DOI: 10.3389/fonc.2025.1737310 · Frontiers in Oncology · 2026-01-12

## TL;DR

This paper reports a rare case of male breast cancer that mimicked lung cancer, highlighting the challenges in diagnosing such rare and complex cases.

## Contribution

The paper presents a unique case of male occult breast cancer with lung-like features, emphasizing the need for careful differential diagnosis.

## Key findings

- The patient presented with a pulmonary mass resembling primary lung cancer, but it was actually occult breast cancer.
- The case highlights the diagnostic difficulty when tumor features do not align with conventional markers.
- The treatment included chemotherapy and intracranial radiotherapy.

## Abstract

Male breast cancer is an extremely rare form of malignant tumor, and occult breast cancer is also an exceptionally uncommon disease. Given its rarity, diagnosing occult breast cancer in male patients presents significant challenges, and the diagnosis becomes even more difficult when the tumor exhibits characteristics of other neoplasms. For instance, this case report describes a male patient with occult breast cancer presenting with features typical of primary lung cancer. The uniqueness and complexity of this case lie in its clinical presentation: beyond typical axillary lymph node enlargement, the primary imaging feature was an isolated pulmonary mass lesion. This presented significant diagnostic hurdles. For the diagnosis of this case, we administered chemotherapy and intracranial radiotherapy to the patient. Therefore, sharing this rare case aims to heighten clinicians’ awareness of differential diagnoses for metastatic cancer with an unknown primary site, particularly when pathological findings of pulmonary lesions do not align with conventional lung cancer markers.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989), lung cancer (MONDO:0005138)

## Full-text entities

- **Diseases:** pulmonary lesions (MESH:D008171), breast cancer (MESH:D001943), malignant tumor (MESH:D009369), lung cancer (MESH:D008175), Male breast cancer (MESH:D018567)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12832376/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12832376/full.md

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Source: https://tomesphere.com/paper/PMC12832376