# Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis

**Authors:** Jinyan Wu, Kai Xu, Mingyue Yin, Xianming Ding, Tong Wang, Qiubo Zhang, Xiaowei Wu, Ningkun Xiao

PMC · DOI: 10.3389/fnut.2025.1745472 · Frontiers in Nutrition · 2026-01-12

## TL;DR

This study shows that caffeine improves cycling performance, with low doses being as effective as higher ones.

## Contribution

The study provides a meta-analysis on caffeine's effect on cycling performance, highlighting dosage and age as key factors.

## Key findings

- Caffeine significantly reduced cycling completion time and increased mean power output.
- Low caffeine doses (≤3 mg/kg) were more effective than higher doses in reducing completion time.
- Age significantly moderated the effect of caffeine on cycling performance.

## Abstract

This study aimed to determine the effects of acute caffeine ingestion on cycling performance through a systematic review and meta-analysis, while also exploring the moderating roles of caffeine dosage, training status, and athlete age. A comprehensive search was conducted across five databases, yielding 20 eligible studies with a total of 226 participants. A three-level mixed-effects model was applied to pool main effects on cycling time trial performance, mean power output, mean heart rate, and ratings of perceived exertion (RPE). Subgroup analyses and meta-regression were performed to examine potential moderators. Caffeine intake significantly reduced cycling completion time (SMD = −0.36, 95% CI: −0.57 to −0.15, p = 0.0017) and increased mean power output (SMD = 0.29, 95% CI: 0.05 to 0.52, p = 0.02), but had no significant effect on heart rate or RPE. Subgroup analysis indicated that a low dose of caffeine (≤3 mg/kg; SMD = −0.42) was more effective in reducing completion time compared with a higher dose (4–6 mg/kg; SMD = −0.34). Meta-regression further revealed a significant moderating effect of age on time trial performance (β = −0.0501; p = 0.02). Taken together, these findings suggest that ingesting caffeine approximately one hour before exercise can effectively enhance cycling performance, with low doses achieving improvements comparable to higher doses.

## Linked entities

- **Chemicals:** caffeine (PubChem CID 2519)

## Full-text entities

- **Chemicals:** Caffeine (MESH:D002110)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12832238/full.md

## References

67 references — full list in the complete paper: https://tomesphere.com/paper/PMC12832238/full.md

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Source: https://tomesphere.com/paper/PMC12832238