# A challenging diagnosis of interstitial ectopic pregnancy confounded by sonographic signs of adenomyosis: a case report

**Authors:** Grace Sutherland, Sophie Putt, Kapilesh Balachandar, Mark Ruff, Sashi Siva

PMC · DOI: 10.1093/jscr/rjag003 · Journal of Surgical Case Reports · 2026-01-25

## TL;DR

A rare case of interstitial ectopic pregnancy was misdiagnosed due to sonographic signs resembling adenomyosis, highlighting the need for careful evaluation in complex pregnancies.

## Contribution

This case report emphasizes the diagnostic challenges of interstitial ectopic pregnancies in the presence of adenomyosis and showcases effective minimally invasive treatment.

## Key findings

- Interstitial ectopic pregnancy was initially misdiagnosed due to adenomyosis-related sonographic features.
- Laparoscopic surgery with hemostatic agents successfully treated the ectopic pregnancy with minimal blood loss.
- The case underscores the importance of serial hCG monitoring and specialist ultrasound in ambiguous pregnancy presentations.

## Abstract

Interstitial ectopic pregnancies account for 1%–3% of ectopic pregnancies and carry a high risk of morbidity due to delayed diagnosis and potential catastrophic haemorrhage. Sonographic identification is challenging and may be further confounded by distorted pelvic anatomy, including adenomyosis, which can present with myometrial cysts or sub-endometrial microcysts that mimic a gestational sac.

We describe a 36-year-old woman presenting with early-pregnancy bleeding whose initial ultrasounds suggested a possible intrauterine pregnancy due to adenomyosis-related cystic changes. Serial serum human chorionic gonadotropin (hCG) levels rose sub-optimally, and specialist ultrasound ultimately confirmed a right interstitial ectopic pregnancy. She underwent successful laparoscopic uterine wedge resection and bilateral salpingectomy with the use of intramyometrial vasopressin and tranexamic acid to minimize blood loss. This case highlights the importance of vigilance in pregnancies of unknown location, particularly when adenomyosis distorts sonographic anatomy, and demonstrates the role of minimally invasive techniques and haemostatic adjuncts in reducing morbidity.

## Linked entities

- **Chemicals:** vasopressin (PubChem CID 8230), tranexamic acid (PubChem CID 5526)
- **Diseases:** adenomyosis (MONDO:0010888)

## Full-text entities

- **Genes:** CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}
- **Diseases:** adenomyosis (MESH:D062788), Interstitial ectopic pregnancies (MESH:D065167), blood loss (MESH:D016063), myometrial cysts (MESH:D003560), bleeding (MESH:D006470), ectopic pregnancies (MESH:D011271)
- **Chemicals:** tranexamic acid (MESH:D014148), intramyometrial vasopressin (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12832011/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12832011/full.md

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Source: https://tomesphere.com/paper/PMC12832011