# From Repair to Prevention: The Emerging Role of Preventive Orthopedics

**Authors:** Hiram E Luigi Martinez, José Pablo Bibiloni Lugo, Leslian Vélez-Ramos, Ammar N Saigal, Rafael Señeriz Ortiz

PMC · DOI: 10.7759/cureus.100008 · Cureus · 2025-12-24

## TL;DR

This paper reviews strategies to prevent musculoskeletal issues like back pain and osteoarthritis, emphasizing lifestyle changes and new technologies to reduce healthcare costs and improve outcomes.

## Contribution

The paper introduces a comprehensive framework for preventive orthopedics integrating lifestyle, digital health, and pharmacologic approaches.

## Key findings

- Preventive orthopedic strategies reduce injury rates and improve pain and function.
- Digital health technologies and workplace programs show promise in preventing MSK disorders.
- Pharmacologic strategies like GLP-1-based weight management are emerging as prevention tools.

## Abstract

Musculoskeletal (MSK) conditions are leading causes of global disability and major drivers of healthcare utilization, surgeries, and productivity loss, with low back pain, osteoarthritis, and fragility fractures contributing most to the burden and expected to rise due to aging, obesity, and sedentary lifestyles. Work-related MSK disorders remain highly prevalent and are costly. This narrative review aimed to synthesize current preventive orthopedic strategies across the life course. Evidence was drawn from systematic reviews, meta-analyses, clinical guidelines, economic evaluations, and targeted searches, following best-practice standards for transparent narrative reviews. Preventive orthopedics integrates risk stratification; neuromuscular and ergonomic interventions; lifestyle-first osteoarthritis management; fall and fracture prevention, including osteoporosis screening and fracture liaison services; workplace MSK programs; perioperative prehabilitation; digital health technologies; and emerging pharmacologic strategies such as glucagon-like peptide-1 (GLP-1)-based weight management. These interventions demonstrate reductions in injury rates, improvements in pain and function, and meaningful health system efficiencies. Persistent challenges include adherence, implementation fidelity, reporting quality, and equitable access. Future priorities include pragmatic and equity-focused trials and clearer operationalization of prevention across musculoskeletal care pathways.

## Linked entities

- **Chemicals:** glucagon-like peptide-1 (PubChem CID 16133831)
- **Diseases:** osteoarthritis (MONDO:0005178), osteoporosis (MONDO:0005298)

## Full-text entities

- **Genes:** GCG (glucagon) [NCBI Gene 2641] {aka GLP-1, GLP1, GLP2, GRPP}
- **Diseases:** fall (MESH:C537863), fragility fractures (MESH:D005600), fracture (MESH:D050723), pain (MESH:D010146), MSK disorders (MESH:D009140), obesity (MESH:D009765), osteoarthritis (MESH:D010003), low back pain (MESH:D017116), osteoporosis (MESH:D010024)

## Full text

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## References

72 references — full list in the complete paper: https://tomesphere.com/paper/PMC12831487/full.md

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Source: https://tomesphere.com/paper/PMC12831487