# Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches

**Authors:** Valentina Burckhardt-Bravo, Rodrigo Funes-Ferrada, Fernando Valenzuela

PMC · DOI: 10.1016/j.abd.2025.501249 · Anais Brasileiros de Dermatologia · 2026-01-15

## TL;DR

This review discusses new acne treatments that focus on improving skin health without harsh medications.

## Contribution

The paper introduces non-pharmacological and microbiome-based acne treatments as novel therapeutic approaches.

## Key findings

- Recent studies show promising results for microbiome modulation in treating acne.
- Non-pharmacological approaches may offer safer and more tolerable alternatives to traditional treatments.

## Abstract

Acne vulgaris is a chronic inflammatory condition with multifactorial pathogenesis. Despite the availability of numerous treatment options, there remains a need for safe, well-tolerated, and microbiome-preserving therapies. This narrative review explores recent advances in non-pharmacological acne treatments, focusing on various microbiome modulation strategies. It highlights emerging therapeutic modalities and their potential impact on clinical practice. Key findings from recent studies are summarized, providing insights for future research and practical applications in dermatology.

## Linked entities

- **Diseases:** acne vulgaris (MONDO:0011438)

## Full-text entities

- **Genes:** TSLP (thymic stromal lymphopoietin) [NCBI Gene 85480], IL33 (interleukin 33) [NCBI Gene 90865] {aka C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV}
- **Diseases:** skin condition (MESH:D012871), -inflammatory lesions (MESH:D007249), LBPs (MESH:D007787), chronic (MESH:D002908), Dysbiosis (MESH:D064806), ORCID ID (MESH:C537985), seborrhea (MESH:D012628), cytotoxicity (MESH:D064420), condition (MESH:D020763), papules (MESH:D000169), Erythema (MESH:D004890), epidermal hyperplasia (MESH:D006965), Acne (MESH:D000152), immune dysregulation (OMIM:614878), desquamation (MESH:D017490)
- **Chemicals:** PpIX (MESH:C028025), DHA (MESH:C027493), Curcumin (MESH:D003474), 5-Aminolevulinic Acid (MESH:C000614854), hyaluronic acid (MESH:D006820), adapalene (MESH:D000068816), ALA (MESH:D000622), benzoyl peroxide (MESH:D001585), GLA (MESH:D017965), ROS (MESH:D017382), succinic acid (MESH:D019802), retinoids (MESH:D012176), B244 (-), lupeol (MESH:C010480), IAA (MESH:C030737), Omega-3 fatty acids (MESH:D015525), lactic acid (MESH:D019344), free fatty acid (MESH:D005230), lipid (MESH:D008055), fatty acid (MESH:D005227), niacinamide (MESH:D009536), Isotretinoin (MESH:D015474)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bacillus (genus) [taxon 55087], Limnospira platensis (species) [taxon 118562], Cutibacterium acnes (species) [taxon 1747], Lactobacillus acidophilus (species) [taxon 1579], Camellia sinensis (black tea, species) [taxon 4442], Lactococcus (lactic streptococci, genus) [taxon 1357], Escherichia coli (E. coli, species) [taxon 562], Pseudomonas (RNA similarity group I, genus) [taxon 286], Bifidobacterium animalis subsp. lactis (subspecies) [taxon 302911], Mus musculus (house mouse, species) [taxon 10090], Staphylococcus aureus (species) [taxon 1280], Enterococcus faecalis (species) [taxon 1351], C. sinensis [taxon 128511], Lacticaseibacillus rhamnosus GG (strain) [taxon 568703], Ammonia (genus) [taxon 29189], Morinda citrifolia (awl tree, species) [taxon 43522], Mycobacterium (genus) [taxon 1763], Lacticaseibacillus paracasei (species) [taxon 1597], Staphylococcus epidermidis (species) [taxon 1282]

## Full text

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## Figures

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## References

52 references — full list in the complete paper: https://tomesphere.com/paper/PMC12830251/full.md

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Source: https://tomesphere.com/paper/PMC12830251